2010 Spring BME 247-01
Bulletin Course Description Introduction to drug delivery in solid tumors and normal organs (for example, reproductive organs, kidney, skin, eyes). Emphasis on quantitative analysis of drug transport. Specific topics include: physiologically-based pharmacokinetic analysis, microcirculation, network analysis of oxygen transport, transvascular transport, interstitial transport, transport across cell membrane, specific issues in the delivery of cells and genes, drug delivery systems, and targeted drug delivery. Instructor: Yuan
(Instructor named in bulletin description above may not be current. For current instructor, see listing below.)
Title DRUG DELIVERY Department BME Course Number 2010 Spring 247 Section Number 01 Primary Instructor Yuan,Fan Prerequisites Prerequisite: Biomedical Engineering 207.
Synopsis of course content
This is a survey course on drug delivery in solid tumors and normal organs. The course emphasizes quantitative analysis of drug transport. Various engineering-related topics on drug and gene delivery are discussed. These topics include physiologically-based pharmacokinetic analysis, microcirculation, transvascular transport, interstitial transport, transport across cell membrane, drug carriers, controlled drug release, targeted delivery of drugs, oxygen transport, delivery of effector cells and genes. As of Spring 2009, a new prerequisite was added that students must have MATLAB Software.
Additional Information
The course contains 6-8 virtual lab experiments and computer projects. They are all based on MATLAB. In the past, students who took this course without MATLAB background had trouble doing these projects. Thus, the TAs had to spend a huge amount of time to help them coding in MATLAB. The added prerequisite has minimal impact on Duke undergraduate students since they have all take EGR 53.
