2007 Fall BIOLOGY 118-001
Bulletin Course Description Explores flow of information from gene to phenotype. Social implications of modern genetic analysis and the genomic revolution. Topics include: organization and stability of genomes from bacteria to higher vertebrates (humans), conversion of the genetic code into a functioning organism, classical transmission (Mendelian) genetics and its relevance to human hereditary disorders, content of the genome and social implications of genetic knowledge including issues of genetic privacy, eugenics, genetically modified organism, and cloning. Instructor: Bejsovec, Haase, Mitchell-Olds, Sun, or staff
(Instructor named in bulletin description above may not be current. For current instructor, see listing below.)
Title GENETICS AND MOLECULAR BIOLOGY Department BIOLOGY Course Number 2007 Fall 118 Section Number 001 Primary Instructor Spana,Eric P Primary Instructor Bejsovec,Amy Prerequisites Prerequisite: Biology 25L or equivalent; Chemistry 31L or equivalent.
Prerequisites
Introductory Biology (Bio 25 or the equivalent)and Chem 22L
Synopsis of course content
Topics covered:
General overview of an Eukaryotic cell
Protein structure and function
The phospholipid bilayer and cellular compartments
Nucleic acid structure and function
Cloning and sequencing a whole genome
Genomic structure - genes, introns, intergenic spacers
Cloning and analyzing a specific gene
DNA replication and chromosome structure
Mutation and DNA repair
Cytoskeleton
Mitosis and meiosis
Mendelian genetics
Polygenic inheritance
Recombination and mapping in eukaryotes
Molecular mechanisms of recombination
Transposons
Chromosomal rearrangements and cytogenetics
Human gene mapping and positional cloning
Genetic diseases and diagnostic testing
Transgenic technology and gene therapy
Transcriptional regulation
Post-transcriptional regulation
Translation
Eukaryotic cell cycle
Cancer biology
Textbooks
Griffiths et al., Modern Genetic Analysis, 2nd edition
Alberts et al., Molecular Biology of the Cell, 4th edition
Assignments
Problem sets Discussion
Exams
Two one hr exams during the semester and one three hour final
Term Papers
None
Grade to be based on
Examination in class
Additional Information
Discussion sections will clarify lecture material and provide help with problem sets
